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Present we present letter a semisynthesis approach that provides access to N-terminally-modified variants of human thymidine monophosphate kinase (TMPK). This enzyme is closely involved in causative nucleoside-based drugs manageable against viral infections such as HIV and against definite types of cancers.Author: Lars Gogolin, Ralf Seidel, Martin Engelhard, Roger S. Delicacy, Christian F. Atomic number 74. BeckerCited by: Bring out Year: 2010
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- Semisynthesis of human thymidine monophosphate kinase in 2021
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Semisynthesis of human thymidine monophosphate kinase in 2021
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How are thymidine kinases different in different species?
The kinetics of TK from different species differ from each other's and also the different forms from a given species (monomer, dimer, tetramer and serum form) have different kinetic characteristics. Genes for virus specific thymidine kinases have been identified in Herpes simplex virus, Varicella zoster virus and Epstein-Barr virus.
Why is thymidine kinase required for yeast replication?
This provides DNA replication profiles of individual molecules. This requires that the yeast strains express thymidine kinase, which wild type yeasts do not, being fungi (see occurrence). Therefore, a gene for thymidine kinase must be incorporated in the genome.
Which is the product of thymidine monophosphate reaction?
Thymidine monophosphate, the product of the reaction catalyzed by thymidine kinase, is in turn phosphorylated to thymidine diphosphate by the enzyme thymidylate kinase and further to thymidine triphosphate by the enzyme nucleoside diphosphate kinase.
Last Update: Oct 2021